Heterocyclic prostaglandins. III. Synthesis of 10-oxa-11-deoxyprostaglandin E2.
نویسندگان
چکیده
منابع مشابه
Inhibition of bronchoconstriction by aerosols of prostaglandins E1 and E2.
The proposal that some naturally occurring prostaglandins (PGs) or their by-products may be implicated in the pathogenesis of the asthmatic bronchospasm has been suggested. Other PGs may be potentially useful in the treatment of this lung disease. The present investigation compared the bronchodilator effects of PGE1 and PGE2 in pharmacologically constricted experimental animals. In pentobarbita...
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An increasing number of proteins are being shown to have an N -carboxylated lysine in their structures, a posttranslational modification of proteins that proceeds without the intervention of a specific enzyme. The role of the carboxylated lysine in theseproteins is typically structural (hydrogen bonding or metal coordination). However, carboxylated lysines in the active sites of OXA-10 and OXA-...
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During the last several decades, an intensive search for endogenous sleep-regulating substances has been carried out in a number of laboratories throughout the world (see Ref. 1 for a general review). In this article, I wish to briefly review current knowledge about the sleep-regulating activity of prostaglandins and to propose the working hypothesis that prostaglandins (PG)' DZ and Ez induce s...
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Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1980
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.28.783